LONG-TERM EXPERIMENTAL EVOLUTION REVEALS PURIFYING SELECTION ON PIRNA-MEDIATED CONTROL OF TRANSPOSABLE ELEMENT EXPRESSION

Long-term experimental evolution reveals purifying selection on piRNA-mediated control of transposable element expression

Abstract Background Transposable elements (TEs) are an almost universal constituent of eukaryotic genomes.In animals, Piwi-interacting small RNAs (piRNAs) and repressive chromatin often play crucial roles in preventing TE transcription and thus restricting TE activity.Nevertheless, TE content varies widely across eukaryotes and the dynamics of TE a

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Designing a potent multivalent epitope vaccine candidate against Orientia tsutsugamushi via reverse vaccinology technique - bioinformatics and immunoinformatic approach

Scrub typhus is a life-threatening, undifferentiated febrile illness caused by a gram-negative bacterium, Orientia tsutsugamushi.The bacterial strain is a global health concern that should be considered.Despite several years of effort for the development of an effective immunogenic vaccine, no successful licensed vaccine is available.The aim of the

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